Manage risky situations is a team game. And the experience gained in this direction in the space can be useful in daily life as well as in contexts where it is important to not make false steps, like that of an operating room of a hospital. This is the summary of the lesson Paolo Nespoli, who, strong of the experience gained in the three missions conducted with the European Space Agency, spoke to the students of the High School in Economics and health Systems Management (ALTEMS) of the Faculty of Economics of the Catholic University of Rome. Title of the meeting-lecture: “Beyond the high reliability: risk and safety in the aerospace industry”.